diff --git a/llvm/lib/Passes/PassBuilder.cpp b/llvm/lib/Passes/PassBuilder.cpp
index fb56a6f05d36..4845bd2957b3 100644
--- a/llvm/lib/Passes/PassBuilder.cpp
+++ b/llvm/lib/Passes/PassBuilder.cpp
@@ -437,6 +437,11 @@ static void addPGOInstrPasses(ModulePassManager &MPM, bool DebugLogging,
     MPM.addPass(createModuleToPostOrderCGSCCPassAdaptor(std::move(CGPipeline)));
   }
 
+  // Delete anything that is now dead to make sure that we don't instrument
+  // dead code. Instrumentation can end up keeping dead code around and
+  // dramatically increase code size.
+  MPM.addPass(GlobalDCEPass());
+
   if (RunProfileGen) {
     MPM.addPass(PGOInstrumentationGen());
 
diff --git a/llvm/test/Transforms/GlobalDCE/externally_available.ll b/llvm/test/Transforms/GlobalDCE/externally_available.ll
index fca49b29ec8e..bc54db38cee0 100644
--- a/llvm/test/Transforms/GlobalDCE/externally_available.ll
+++ b/llvm/test/Transforms/GlobalDCE/externally_available.ll
@@ -1,12 +1,21 @@
 ; RUN: opt < %s -globaldce -S | FileCheck %s
 
+; test_global should not be emitted to the .s file.
+; CHECK-NOT: @test_global =
+@test_global = available_externally global i32 4
+
+; test_global2 is a normal global using an available externally function.
+; CHECK: @test_global2 =
+@test_global2 = global i32 ()* @test_function2
+
 ; test_function should not be emitted to the .s file.
-; CHECK-NOT: test_function
+; CHECK-NOT: define {{.*}} @test_function()
 define available_externally i32 @test_function() {
   ret i32 4
 }
 
-; test_global should not be emitted to the .s file.
-; CHECK-NOT: test_global
-@test_global = available_externally global i32 4
-
+; test_function2 isn't actually dead even though it's available externally.
+; CHECK: define available_externally i32 @test_function2()
+define available_externally i32 @test_function2() {
+  ret i32 4
+}