diff --git a/compiler-rt/cmake/config-ix.cmake b/compiler-rt/cmake/config-ix.cmake
index 28051dad6e54..21af345dc6bb 100644
--- a/compiler-rt/cmake/config-ix.cmake
+++ b/compiler-rt/cmake/config-ix.cmake
@@ -500,6 +500,10 @@ if(APPLE)
     endforeach()
   endif()
 
+  # Explictly disable unsupported Sanitizer configurations.
+  list(REMOVE_ITEM FUZZER_SUPPORTED_OS "watchos")
+  list(REMOVE_ITEM FUZZER_SUPPORTED_OS "watchossim")
+
   # for list_intersect
   include(CompilerRTUtils)