diff --git a/llvm/lib/Transforms/Scalar/LoopRotation.cpp b/llvm/lib/Transforms/Scalar/LoopRotation.cpp
index 2606805400fd..4d1234905370 100644
--- a/llvm/lib/Transforms/Scalar/LoopRotation.cpp
+++ b/llvm/lib/Transforms/Scalar/LoopRotation.cpp
@@ -535,6 +535,8 @@ bool LoopRotate::rotateLoop(Loop *L, bool SimplifiedLatch) {
       Loop *PredLoop = LI->getLoopFor(*PI);
       if (!PredLoop || PredLoop->contains(Exit))
         continue;
+      if (isa<IndirectBrInst>((*PI)->getTerminator()))
+        continue;
       SplitLatchEdge |= L->getLoopLatch() == *PI;
       BasicBlock *ExitSplit = SplitCriticalEdge(
           *PI, Exit, CriticalEdgeSplittingOptions(DT, LI).setPreserveLCSSA());
diff --git a/llvm/test/Transforms/LoopRotate/crash.ll b/llvm/test/Transforms/LoopRotate/crash.ll
index fd922cb5569e..e95f9a1f350f 100644
--- a/llvm/test/Transforms/LoopRotate/crash.ll
+++ b/llvm/test/Transforms/LoopRotate/crash.ll
@@ -153,3 +153,21 @@ entry:
 "5":                                              ; preds = %"3", %entry
   ret void
 }
+
+; PR21968
+define void @test8(i1 %C, i8* %P) #0 {
+entry:
+  br label %for.cond
+
+for.cond:                                         ; preds = %for.inc, %entry
+  br i1 %C, label %l_bad, label %for.body
+
+for.body:                                         ; preds = %for.cond
+  indirectbr i8* %P, [label %for.inc, label %l_bad]
+
+for.inc:                                          ; preds = %for.body
+  br label %for.cond
+
+l_bad:                                            ; preds = %for.body, %for.cond
+  ret void
+}