diff --git a/openmp/CMakeLists.txt b/openmp/CMakeLists.txt
index b8662ba9cfb4..a204266f4ecb 100644
--- a/openmp/CMakeLists.txt
+++ b/openmp/CMakeLists.txt
@@ -4,6 +4,9 @@ set(OPENMP_LLVM_TOOLS_DIR "" CACHE PATH "Path to LLVM tools for testing")
 
 add_subdirectory(runtime)
 
-if (NOT WIN32)
+# Currently libomptarget cannot be compiled on Windows or MacOS X.
+# Since the device plugins are only supported on Linux anyway,
+# there is no point in trying to compile libomptarget on other OSes.
+if (NOT (WIN32 OR ${CMAKE_SYSTEM_NAME} MATCHES "Darwin"))
   add_subdirectory(libomptarget)
 endif()