Notmuch is an answer to Sup. Sup is a very good email program written by
William Morgan (and others) and is the direct inspiration for Notmuch.
Notmuch began as an effort to rewrite performance-critical pieces of Sup in
C rather than ruby. From there, it grew into a separate project. One
significant contribution Notmuch makes compared to Sup is the separation
of the indexer/searcher from the user interface. (Notmuch provides a
library interface so that its indexing/searching/tagging features can be
integrated into any email program.)
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