diff --git a/academic/ugene/ugene-1.22.0-dont_hardcode_includes.patch b/academic/ugene/ugene-1.22.0-dont_hardcode_includes.patch
deleted file mode 100644
index 6bc26e1f19..0000000000
--- a/academic/ugene/ugene-1.22.0-dont_hardcode_includes.patch
+++ /dev/null
@@ -1,24 +0,0 @@
-diff -up ugene-1.22.0/src/libs_3rdparty/samtools/samtools.pri.dont_hardcode_includes ugene-1.22.0/src/libs_3rdparty/samtools/samtools.pri
---- ugene-1.22.0/src/libs_3rdparty/samtools/samtools.pri.dont_hardcode_includes	2016-03-31 07:21:56.000000000 -0500
-+++ ugene-1.22.0/src/libs_3rdparty/samtools/samtools.pri	2016-06-02 17:49:02.383069490 -0500
-@@ -3,7 +3,7 @@ UGENE_RELATIVE_DESTDIR = ''
- 
- TEMPLATE = lib
- CONFIG +=thread debug_and_release staticlib warn_off
--INCLUDEPATH += src src/samtools ../../include /usr/include
-+INCLUDEPATH += src src/samtools ../../include
- win32 : INCLUDEPATH += src/samtools/win32
- DEFINES+="_FILE_OFFSET_BITS=64" _LARGEFILE64_SOURCE _USE_KNETFILE
- win32 : DEFINES += _USE_MATH_DEFINES "inline=__inline" "__func__=__FUNCTION__" "R_OK=4" "atoll=_atoi64" "alloca=_alloca"
-diff -up ugene-1.22.0/src/plugins_3rdparty/variants/variants.pri.dont_hardcode_includes ugene-1.22.0/src/plugins_3rdparty/variants/variants.pri
---- ugene-1.22.0/src/plugins_3rdparty/variants/variants.pri.dont_hardcode_includes	2016-03-31 07:22:09.000000000 -0500
-+++ ugene-1.22.0/src/plugins_3rdparty/variants/variants.pri	2016-06-02 20:26:35.265356432 -0500
-@@ -20,7 +20,7 @@ use_bundled_zlib() {
- win32 : LIBS += -lwsock32
- 
- 
--INCLUDEPATH += src ../../include /usr/include
-+INCLUDEPATH += src ../../include
- INCLUDEPATH += ../../libs_3rdparty/samtools/src/samtools 
- INCLUDEPATH += ../../libs_3rdparty/samtools/src
- INCLUDEPATH += ../../libs_3rdparty/samtools/src/samtools/bcftools
diff --git a/academic/ugene/ugene.SlackBuild b/academic/ugene/ugene.SlackBuild
index 9ebc39636d..0fa277e794 100644
--- a/academic/ugene/ugene.SlackBuild
+++ b/academic/ugene/ugene.SlackBuild
@@ -2,7 +2,7 @@
 
 # Slackware build script for ugene
 
-# Copyright 2013-2020 Petar Petrov slackalaxy@gmail.com
+# Copyright 2013-2021 Petar Petrov slackalaxy@gmail.com
 # All rights reserved.
 #
 # Redistribution and use of this script, with or without modification, is
@@ -23,7 +23,7 @@
 #  ADVISED OF THE POSSIBILITY OF SUCH DAMAGE.
 
 PRGNAM=ugene
-VERSION=${VERSION:-35.0}
+VERSION=${VERSION:-38.1}
 BUILD=${BUILD:-1}
 TAG=${TAG:-_SBo}
 
@@ -73,9 +73,6 @@ find -L . \
  \( -perm 666 -o -perm 664 -o -perm 640 -o -perm 600 -o -perm 444 \
  -o -perm 440 -o -perm 400 \) -exec chmod 644 {} \;
 
-# Thanks fedora
-patch -p1 < $CWD/ugene-1.22.0-dont_hardcode_includes.patch
-
 # Fix libraries and man pages paths
 sed -i "s:/lib:/lib${LIBDIRSUFFIX}:g" src/ugene_globals.pri
 sed -i "s:/share/man:/man:g" src/ugene_globals.pri
@@ -92,7 +89,7 @@ find $PKG -print0 | xargs -0 file | grep -e "executable" -e "shared object" | gr
 
 mkdir -p $PKG/usr/doc/$PRGNAM-$VERSION
 cp -a \
-  build.txt README.md LICENSE.txt LICENSE.3rd_party.txt \
+  README.md LICENSE.txt LICENSE.3rd_party.txt \
   $PKG/usr/doc/$PRGNAM-$VERSION
 cat $CWD/$PRGNAM.SlackBuild > $PKG/usr/doc/$PRGNAM-$VERSION/$PRGNAM.SlackBuild
 
diff --git a/academic/ugene/ugene.info b/academic/ugene/ugene.info
index 6c1efb058c..3c98a2c536 100644
--- a/academic/ugene/ugene.info
+++ b/academic/ugene/ugene.info
@@ -1,8 +1,8 @@
 PRGNAM="ugene"
-VERSION="35.0"
+VERSION="38.1"
 HOMEPAGE="http://ugene.net/"
-DOWNLOAD="https://github.com/ugeneunipro/ugene/archive/35.0/ugene-35.0.tar.gz"
-MD5SUM="c1cb1ee73140d09568706f1fc1b798dd"
+DOWNLOAD="https://github.com/ugeneunipro/ugene/archive/38.1/ugene-38.1.tar.gz"
+MD5SUM="4add1b1c0216ce42e588e982a3d7147e"
 DOWNLOAD_x86_64=""
 MD5SUM_x86_64=""
 REQUIRES=""