diff --git a/drivers/vfio/pci/vfio_pci.c b/drivers/vfio/pci/vfio_pci.c
index 7fe2748ba101..9979d3ba9e52 100644
--- a/drivers/vfio/pci/vfio_pci.c
+++ b/drivers/vfio/pci/vfio_pci.c
@@ -1193,6 +1193,19 @@ static int vfio_pci_probe(struct pci_dev *pdev, const struct pci_device_id *id)
 	if (pdev->hdr_type != PCI_HEADER_TYPE_NORMAL)
 		return -EINVAL;
 
+	/*
+	 * Prevent binding to PFs with VFs enabled, this too easily allows
+	 * userspace instance with VFs and PFs from the same device, which
+	 * cannot work.  Disabling SR-IOV here would initiate removing the
+	 * VFs, which would unbind the driver, which is prone to blocking
+	 * if that VF is also in use by vfio-pci.  Just reject these PFs
+	 * and let the user sort it out.
+	 */
+	if (pci_num_vf(pdev)) {
+		pci_warn(pdev, "Cannot bind to PF with SR-IOV enabled\n");
+		return -EBUSY;
+	}
+
 	group = vfio_iommu_group_get(&pdev->dev);
 	if (!group)
 		return -EINVAL;